Emerging Nutraceuticals For Metabolic Cardiology | Part 2

Introduction

The heart’s primary role in the cardiovascular system is to make sure that blood, nutrients, and hormones are being transported throughout the entire body. The cardiovascular system is consist of the arteries, veins, and blood vessels that are throughout the body and this system make sure to pump blood into the organs and tissues. When there are pathogens that cause the cardiovascular system to develop cardiac risk factors, it can cause many chronic issues over time and can potentially harm the body. In this 2 part series, we will be taking a look at what is diastolic dysfunction in the cardiovascular system and how different nutraceuticals can prevent heart disease from rising in the body. Part 1 took a look into what is cardiac metabolism and how HCTP can help renew the cardiovascular system. By referring patients to qualified and skilled providers who specialized in cardiovascular services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

What Is Diastolic Dysfunction?

The diastolic function requires more cellular energy than systolic contraction as higher concentrations of ATP are required to activate calcium pumps necessary to facilitate cardiac relaxation and diastolic filling. Studies show that diastolic dysfunction is a collective number of issues from hypertension, diabetes, age, and left ventricular hypertrophy that causes increased levels of cardiac oxidative stress and cardiac ROS in the heart.

Surprisingly, diastolic dysfunction is more common in women with hypertension, IHSS, MVP, and infiltrative cardiomyopathy, and the best way to know the early signs of myocardial failure due to diastolic despite the adequate systolic function in the heart. The energetic imbalance of diastolic heart failure is characterized by an increase in energy demand and a decrease in energy production, transfer, and substrate utilization resulting in an ATP deficit. The biopsies of heart tissue in heart failure
patients reveal diminished quantities of ATP in the mitochondria and studies show that diastolic heart failure occurs when the left ventricle is unable to accept adequate volumes of blood.

HCTP Therapy

*Stem cells or HCTP (human cellular tissue products) are used in therapeutic regenerative treatments that affiliated clinics and distribution organizations (both international and national) provide for anyone that needs treatment. HCTP therapy utilizes HCTP to help repair and regenerate damaged cells, tissues, and organs back to their original state. As research studies continue to look into HCTP therapy, the result shows that HCTP can help rescue damaged heart cells and regenerate new heart muscle cells after the individual has been affected by cardiovascular diseases. Part 1 explains more about how HCTP can help repair damaged heart cells.

Nutraceuticals For Heart Disease

Surprisingly though there are nutraceuticals that can help dampen the effects of heart disease and help improve diastolic function to be regulated at normal levels. Studies have shown that even though cardiovascular disease ranks as the most common health issue, by providing several heart-healthy food and dietary supplements has been shown to protect against the development of cardiovascular diseases. Some of the nutraceuticals that can help lower the risk of heart disease are:

• CoQ10
• L-carnitine
• D-ribose

CoQ10

Studies have shown that CoenzymeQ10 or CoQ10 can help decrease levels of neurodegenerative diseases, fibromyalgia, diabetes, and heart failure in the body. This essential compound has helped synthesized the mitochondrial inner membrane of the human body while also becoming the key component to transport electron chains in the cellular mitochondria, which is absolutely necessary for ATP production.

CoQ10 Effects

Since CoQ10 is a ubiquitous factor that is presented in the cell membranes and the mitochondria, research shows that CoQ10 has significant antioxidant and anti-inflammatory properties that can provide therapeutic results for individuals with cardiovascular diseases. Some of the beneficial effects that CoQ10 can offer to the heart include:

• Reduces Lp(a)
• Improves endothelial function
• Decreases cholesterol/triglyceride levels
• Increases HDL
• Decreases FBS/HbA1c
• Reduces lipoprotein (LDL) oxidation
• Reduces systolic/diastolic blood pressure

L-carnitine

L-carnitine is a trimethylated amino acid-like cofactor for the transport of free long-chain fatty acids in the mitochondrial matrix where beta-oxidation occurs for cellular energy production. L-carnitine was originally isolated from meat in 1905 and it plays a crucial role in metabolism as it was discovered in 1955. Studies have shown that when patients are undergoing hemodialysis will often have carnitine deficiencies, which will result in cardiac dysfunction. However, like CoQ10, carnitine deficiency is usually not a factor in a healthy, well-nourished population consuming adequate animal protein.

L-carnitine Effects

Some of the beneficial factors that L-carnitine can provide to the body is that it actually plays an important role in transporting long-chain fatty acids from the cytoplasm into various tissues in the body. Other beneficial effects that L-carnitine provides include:

• Beta oxidation of fatty acids – in mitochondria
• 60% of heart energy metabolism of fatty acids
• Removal of lactic acid and other toxic metabolites from blood
• Ammonia detoxification
• Function as antioxidants
• Next-generation – Aminocarnitines

D-ribose

The administration of D-ribose can help with the improvement in diastolic function as D-ribose is used by cells to manage cellular energy restoration. It helps replenish the body as the loss of purines in the ischemic situation can cause a slow process to replace the adenine pool. If D-ribose is not available energy pool, then it cannot be restored and the heart can take about 100 days to restore ATP via de novo synthesis. Studies have found that D-ribose is actually an essential component for the respiratory, skeletal, and nervous systems while providing beneficial effects to the heart.

D-ribose Effects

Research studies have found that D-ribose is a naturally occurring pentose carbohydrate that has beneficial properties by increasing cellular energy levels, improving function that follows ischemia, and dampening the effects of cardiovascular disease. Other beneficial effects that D-ribose can provide include:

• Improves treadmill findings in patients with coronary artery disease
• Better diastolic function, QOL, and functional status in chronic heart failure
• Accelerates the recovery of systolic function post CABG
• Speeds recovery of muscle ATP following anaerobic exercise
• Enhances strength and endurance gain with weight training
• Decreases free radical stress during anaerobic exercise
• Benefit in fibromyalgia

Conclusion

All in all, nutraceuticals are beneficial by dampening the effects of diastolic dysfunction and cardiovascular diseases. When unwanted pathogens start attacking the body, cause many inflammatory problems that can turn into chronic issues over time, causing a person to be miserable. By finding the right kind of vitamins, eating the right foods, and regularly exercising can help the body and cardiovascular system be functional throughout the entire lifetime.

Reference

Jeong, Euy-Myoung, and Samuel C Dudley. “Diastolic Dysfunction.” Circulation Journal: Official Journal of the Japanese Circulation Society, U.S. National Library of Medicine, 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4861951/.

Kaneko, Mai, et al. “L-Carnitine Improved the Cardiac Function via the Effect on Myocardial Fatty Acid Metabolism in a Hemodialysis Patient.” Internal Medicine (Tokyo, Japan), The Japanese Society of Internal Medicine, 15 Dec. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6355401/.

Lalande, Sophie, and Bruce D Johnson. “Diastolic Dysfunction: A Link between Hypertension and Heart Failure.” Drugs of Today (Barcelona, Spain: 1998), U.S. National Library of Medicine, July 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2713868/.

Li, Shuai, et al. “D-Ribose: Potential Clinical Applications in Congestive Heart Failure and Diabetes, and Its Complications (Review).” Experimental and Therapeutic Medicine, D.A. Spandidos, May 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8005739/.

Martelli, Alma, et al. “Coenzyme Q10: Clinical Applications in Cardiovascular Diseases.” Antioxidants (Basel, Switzerland), MDPI, 22 Apr. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7222396/.

Medical Professionals, Cleveland Clinic. “Stem Cell Therapy for Heart Disease.” Cleveland Clinic, 30 Jan. 2019, my.clevelandclinic.org/health/diseases/17508-heart-disease-stem-cell-therapy.

Shecterle, Linda M, et al. “Potential Clinical Benefits of D-Ribose in Ischemic Cardiovascular Disease.” Cureus, Cureus, 9 Mar. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5943027/.

Sood, Brittany, and Michael Keenaghan. “Coenzyme Q10.” StatPearls [Internet]., U.S. National Library of Medicine, 19 Jan. 2022, www.ncbi.nlm.nih.gov/books/NBK531491/.

Sosnowska, Bozena, et al. “The Role of Nutraceuticals in the Prevention of Cardiovascular Disease.” Cardiovascular Diagnosis and Therapy, AME Publishing Company, Apr. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5418215/.

Zozina, Vladlena I, et al. “Coenzyme Q10 in Cardiovascular and Metabolic Diseases: Current State of the Problem.” Current Cardiology Reviews, Bentham Science Publishers, 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6131403/.

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