Circadian rhythm and caffeine supplementation go hand in hand in many sports. Genetic profiling comes in handy when determining if you are a morning person capable of metabolizing a nice cup of coffee or your performance is better in the evening. New technology advances such as DNA testing of specific gene encodings and recent emerging literature suggest a noticeable relation between peak time and caffeine metabolism.Â
Are you a morning person or a night owl?Â
Circadian clocks that comprise clock genes are located in various tissues throughout our body. These circadian clocks regulate our daily physiological events such as hormone synthesis and release and metabolic processes. Our central clock, the pineal gland, is regulated by the light/dark cycles.
Central clock in the suprachiasmatic nucleus (SCN):
- Sleep/wake cycles.
- Controls the autonomic nervous system.
- Modulates the core body temperature.
- Regulates melatonin secretion.
On the other hand, feeding and fasting cycles are the ones that control our peripheral clocks.Â
- Dominate local physiological processes.
- Promote glucose and lipid homeostasis.
- Regulates hormone secretion.
- Modulates immune respose.
- Manages the digestive system.
Core clock genes orchestrate, via a feedback loop, the circadian rhythm throughout our body. One of the primary core clock genes is CLOCK, which has a tight association with the energy metabolism status in various mechanisms.
CLOCK: circadian locomotor output cycles kaput is a clock protein. It is an essential element in the control and modulation of the circadian rhythm. In addition, CLOCK has a strong involvement with metabolic regulation.
Studies show that the NAD(H)/NADP(H)ratio depends on the binding capacity of CLOCK/NPAS2:BMAL1 transcription factors to DNA. In turn, there are several mechanisms dependent on this NAD interaction with circadian rhythm. Indeed, the downstream CLOCK-dependent reactions start with Napt, an encoding gene for restriction enzymes that control NAD+ concentration. Furthermore, NAD+ regulates deacetylase Sirt1, which governs the chromatin remodeling, mediated by CLOCK. Studies show that the disruption of NAD+ oscillation is linked to alteration in the circadian metabolic rhythm in mice.
Is it the time of day limiting your athletic performance?
It is essential to consider that the coding gene CLOCK 3111 is an element involved in regulating the central clock function. Therefore, in a sports context, it may serve as a marker of morning endurance performance. Another aspect to consider is that this gene has a close interaction with body temperature, melatonin release, and lipid utilization. Specific single nucleotide polymorphisms (SNP) in this gene show that C allele carriers have reported feeling fatigued in the morning and prefer having evening activities.
Another encoding gene with great application in the athletic and circadian rhythm context is CYP1A2. This codes for the enzymes that metabolize caffeine. In sports, such as racing, the supplementation of caffeine has been shown to improve performance. However, specific SNPs are associated with better caffeine metabolism. Those individuals carrying the C allele genotype have shown poor ability to metabolize caffeine, increasing their chances of developing heart disease. On the other hand, A allele genotypes metabolize caffeine at a fast rate. In this case, caffeine supplementation 30 min to 1 hour before activity can improve athletic performance in sports like sprint races.
The main objective of gene profiling is to improve athletic results by detecting genetic limitations or enhancing beneficial SNPs. The CLOCK 3111and CYP12A genes have a powerful effect on metabolism and circadian rhythm. Nevertheless, their application on athletic endurance shows that the body can be easily modified with supplementation, in this case, caffeine. – Ana Paola RodrÃguez Arciniega, MS
Mikulska, Aniceta Ada et al. “Assessment of Selected Clock Proteins (CLOCK and CRY1) and Their Relationship with Biochemical, Anthropometric, and Lifestyle Parameters in Hypertensive Patients.”Â BiomoleculesÂ vol. 11,4 517. 30 Mar. 2021, doi:10.3390/biom11040517
Oike, Hideaki et al. “Nutrients, Clock Genes, and Chrononutrition.”Â Current nutrition reportsÂ vol. 3,3 204-212. 27 Apr. 2014, doi:10.1007/s13668-014-0082-6
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Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, CTG*
Licensed in Texas & New Mexico
The information herein on "Are you Born an Athlete? Peak Time and Caffeine Metabolism" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.
Our information scope is limited to Chiropractic, musculoskeletal, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.
We provide and present clinical collaboration with specialists from various disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.
Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and directly or indirectly support our clinical scope of practice.*
Our office has reasonably attempted to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.
We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.
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Dr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
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